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HMB plays a buffering role in your muscles’ metabolism, preventing the build-up of enzymes that directly contribute to muscle protein breakdown (MPB). It’s also believed to stimulate MPS through the activation of certain biochemical pathways within your body. In particular, HMB is believed to activate the mammalian target of rapamycin (mTOR) pathways. Once activated, these pathways help to facilitate the delivery of fresh nutrients to damaged muscle tissues during protein synthesis, helping to replace old broken down muscle proteins with fresh new ones. The Journal of Physiology. Journal of Applied Physiology. American Journal of Physiology. The Journal of Physiology. British Journal of Nutrition. The Journal of Nutrition. European Journal of Applied Physiology. The Journal of Nutritional Biochemistry. The Journal of Nutrition, tamoxifen 20 mg antiestrogens $33.00 nolvadex. Journal of the International Society of Sports Nutrition. Journal of the International Society of Sports Nutrition. Alpha-hydroxy-isocaproic acid, or HICA, is a naturally occurring amino acid metabolite. It’s also sometimes referred to as DL-?-hydroxy-isocaproic acid, leucic acid or DL-2-hydroxy-4-methylvaleric acid. Like HMB, it’s produced during the metabolism of the BCAA leucine. The remainder is metabolized in the muscle into ?-ketoisocaproate (?-KIC) and ?-hydroxy-?-methylbutyrate (HMB). Along the ?-KIC pathways, some of the KIC is also converted into HICA, although it’s a pretty small amount. How does it work? HICA works as an anti-catabolic agent, inhibiting certain enzymes that contribute to the degradation of muscle tissues and a number of experimental and clinical studies have found that it helps to prevent muscle protein breakdown in both animal and human subjects. Some research has also demonstrated that HICA may increase muscle protein synthesis as well. Like it’s closely related cousin HMB, it’s also believed to activate mTOR pathways, although through different mechanisms than HMB. While the findings up to this point seem to be promising, there simply hasn’t been as much research on HICA as there has been on other supplements like creatine.
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