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Exercise is one of the most effective ways to boost HGH production, with an intense strength circuit workout increasing circulating levels of human growth hormone by up to five-fold in some cases ( 2 ). Given the beneficial effects of taking an HGH supplement containing arginine, you might think that taking an HGH supplement right before exercise would be even better when it comes to promoting HGH production. This was what researchers at Syracuse University thought, and they reviewed the scientific literature to test this hypothesis ( 3 ). According to the review article, published in 2008 in the journal Current Opinion in Clinical Nutrition and Metabolic Care, taking arginine in conjunction with exercise actually diminishes the HGH response. It still goes up, but only by about 200% versus the 300-500% increase typically seen in exercise-only studies. It’s not clear why this is’maybe arginine has a limit on how much HGH it can release, and blocks the additional effects of exercise. 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