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L803-MTS relies on the physical structure of the GSK3 protein, which plays a causative role in insulin resistance and sort II diabetes. Working with chemists, biotechnologists and 3-D modelists, Prof. Eldar-Finkelman and her colleagues built ― like engineers constructing a constructing ― a drug that locks onto the GSK3 protein, rendering it harmless and unable to wreak havoc contained in the body. Recent research findings on the L803-MTS drug have been revealed in the Journal of Molecular Biology (2008) and Current Pharmaceutical Design (2009, at present in press). Since Prof. Eldar-Finkelman linked GSK3 to insulin resistance in diabetes greater than ten years ago, a race has been on among drug manufacturers to discover a drug that can potentially flip off the harmful effects of GSK3. But relatively than build on existing drugs, Prof. Eldar-Finkelman and her colleagues worked from the ground up. Pre-clinical outcomes have been positive, קידום אורגני בגוגל and the new drug doesn’t exhibit harmful toxic unwanted side effects, a problem with existing formulations. While L803-MTS can’t reverse the onset of a CNS illness as soon as it has began, Prof. Eldar-Finkelman believes it could possibly decelerate the devastating results of CNS diseases, like impaired memory and depression, or insulin-resistance. With seed cash from Ramot, Tel Aviv University’s technology transfer arm, Prof. Eldar-Finkelman has taken her primary research to the following step, looking for a strategic accomplice to information the analysis via the clinical process and eventual commercialization. Prof. Eldar-Finkelman is now conducting extra pharmacological and toxicological exams on the new compound. This document is topic to copyright. Apart from any honest dealing for the purpose of private examine or research, no part may be reproduced with out the written permission. The content is offered for data purposes solely.
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