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The French in the First World War first used it to make explosives. It was observed that workers exposed to DNP when making explosives experienced weight loss, elevated body temperature, and excessive sweating. DNP’s health risks were unknown at this time, and many deaths would result from this exposure. After a study conducted at Stanford University involving DNP in 1931, it found it’s way into many diet medications, buy hexarelin 2 mg peptides $17.00. It was eventually banned from being sold as a diet aid after several deaths occurred. DNP works by inhibiting FOF1 ATP, the synthase molecule in the body. ATP is used in transferring energy within cells. The body converts adenosine diphosphate into ATP and converts it back to adenosine phosphate after being used. DNP inhibits this synthesis and energy is expelled as heat. DNP has been shown to cause a metabolic increase by a whopping 50 percent. This can result in fat-loss in the range of a pound per day. The metabolic increase associated with DNP results in an increase in body temperature. Unlike many drugs that the body builds a tolerance to over time, DNP’s effects are enhanced the longer its taken. As DNP levels increase in the body, so does body temperature. Any miscalculation in DNP can result in a person literally being cooked from the inside out. If a person’s body temperature climbs to high from DNP use, it can result in permanent brain and organ damage, or even death. Insulin Insulin is a powerful anabolic agent that has been used by bodybuilders for many years. Insulin helps to stimulate the formulation of glycogen from glucose. It also helps amino acids and other nutrients reach muscle cells. Insulin has an influence on other hormones that make it very attractive to bodybuilders. It increases IGF (insulin growth factor) and it increases LH (leutenizing hormone) and FSH (follicle stimulating hormone), both of which increase testosterone production. The increase in testosterone is not much of a benefit to a bodybuilder that’s already taking higher than normal exogenous testosterone, but the increase in amino acid and glycogen uptake from insulin is very anabolic in itself. Insulin has the potential to add a large amount of muscle while increasing strength, but it also has the potential to be very dangerous. There are many protocols that can be used when taking insulin for bodybuilding purposes. All carry a chance of sending an individual into a hypoglycemic state.
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On the next few pages, we’ll present 10 of these non-steroid PEDs, looking at their modes of action and their side effects. Most entries will be individual drugs, but in a few cases, we’ll consider a class of compounds and include some notable examples. Let’s kick everything off with EPO — the drug that ushered in the modern era of doping. Red blood cells carry oxygen throughout the body, so it makes sense that if an athlete can increase his red blood cell count, he’ll deliver more oxygen to his muscles and perform at a higher level. Blood doping — removing and preserving a supply of blood so it can be returned, via transfusion, to the body right before competition — is one way to do this, but it’s messy and time-consuming. Taking erythropoietin , or EPO , increases red blood cell production without the need for transfusions. The kidneys make the hormone naturally, although people with severe kidney disease don’t have enough, buy hexarelin 2 mg peptides $17.00. That’s what the biotechnology firm Amgen was looking to address when it introduced synthetic EPO in 1985. By the 1990s though, cyclists and other endurance athletes had discovered that they could train longer and harder if they took the drug regularly. Not surprisingly, taking EPO comes with significant risk. Studies have shown that it increases the risk of events such as stroke, heart attack and pulmonary edema. One theory suggests that the drug thickens the blood to the point where it produces fatal clots. Such complications may have contributed to the deaths of at least 20 cyclists by 2000, increasing the urgency to develop a reliable test to detect EPO [source: Zorpette]. In 2007, anti-doping agencies introduced the concept of a “biological passport,” a record of the substances found normally in an athlete’s blood and urine, created by repeated sampling over time. By comparing the results of a blood test administered right before a competition to the passport, officials can determine if an athlete has been using EPO or other performance-enhancing drugs. Like EPO, human growth hormone ( hGH ) occurs naturally in the body. In fact, the pituitary gland, the pea-sized organ located at the base of the brain, produces hGH to stimulate growth in children and adolescents and to increase muscle mass in adults. As soon as synthetic hGH became available as a prescription medication in 1985, when the U. Food and Drug Administration approved its use for a number of diseases that retard growth or cause muscle deterioration, athletes began eyeing it as a doping agent. They figured it could mimic the muscle-building effects of anabolic steroids. At first, the high cost of the medication discouraged widespread use as a PED, but, as the saying goes, where there’s a will to win, there’s a way. The 1996 Olympic Games have been called the “hGH Games” because of the rampant use of the drug among competitors. Today, athletes get hGH from a variety of sources: doctors who are willing to write prescriptions for off-label use, Internet pharmacies, illicit Web sites for performance-enhancing drugs and clinics that use the hormone to reverse the effects of aging. A few even turn to black-market dealers that collect hGH from human cadavers. It’s a risky gamble, especially considering the lack of scientific evidence to suggest that hGH actually increases athletic performance. undefined

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