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Oral AAS also carry a greater risk of hepatotoxicity (liver damage) and are associated with potentially harmful changes to the lipid profile (cholesterol) that may increase the risk of cardiovascular events with long-term use, and they do not provide an acceptable risk-to-benefit ratio for many. Among the injectable AAS, certain drugs have withstood the test of time. While it is possible that AAS with more ‘ideal’ properties exist in the archives of pharmaceutical companies, accessibility is an issue that needs to be considered. Patrick Arnold, infamous for his role in the BALCO scandal, synthesized norbolethone’ an AAS developed but never marketed by Wyeth Laboratories, as well as creating THG. However, too little is known about their effect on body composition or potential risks. Most Users Combine AAS It is incorrect to compare AAS based upon ‘popularity’ as that relates to accessibility, and most users combine AAS with the intention of gaining additive benefits. Deca-Durabolin is a trade name for nandrolone decanoate, a 19-nortestosterone AAS. It is familiar to most, and often included in stacks due to its perceived lesser androgenic potency, mood effect and perceptible gains when added to a testosterone-based stack. However, as a solo agent, nandrolone has not gained a following. In part, this is due to its pharmacokinetics’ how long it takes to build up to an effective concentration, and how long it takes to clear from the system. Further, though it is protected from aromatization via the aromatase enzyme complex, it is still capable of being converted into estradiol’ perhaps at 20 percent efficiency compared to testosterone. And while nandrolone is thought of as a ‘less androgenic’ AAS, it is in fact more androgenic than testosterone prior to being acted upon by 5-alpha reductase’ the enzyme that converts testosterone into DHT. It is true that in tissue containing 5-alpha reductase (e, steroide kaufen bodybuilding. However, this does not preclude androgenic effects with anabolic dosing. Lastly, nandrolone also interacts with the progesterone receptor at a relative potency of 10 percent of progesterone (another female sex hormone). Nandrolone is anecdotally associated with AAS-related erectile dysfunction when used as a solo agent, though this is not well documented in the medical literature. Trenbolone: Near-Mythical Status There is one AAS that raises the interest of most experienced bodybuilders. Trenbolone has a near-mythical status due to its discontinuation in 1997. Then, a source for trenbolone was revealed by none other than the late Dan Duchaine, who disclosed a method for extracting trenbolone acetate from pellets designed to enhance meat production after being implanted into cattle. This form of trenbolone was the acetate ester, a shorter-acting but more rapidly bioavailable form that provided exactly the kind of results that the old-school bodybuilders whispered about during the 1970s through the 1990s. Despite the absence of a licensed and approved human pharmaceutical source, several different esters are now widely available through black-market sources, produced with varying quality and purity in ‘underground laboratories. Trenbolone’s reputation is for building muscle size, strength and furnishing a rock-hard physique with a dry appearance. It is most commonly used along with testosterone, as the two used together have reliably provided greater gains than an equivalent testosterone ester single-agent cycle. Also, the gains are believed to be better retained, perhaps in part due to an greater recruitment of satellite cells. This may also aid in ‘muscle memory,’ though this effect has not been noted in anecdotal reports.
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