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If you are taking Femara to increase fertility, take it strictly as directed. Femara should not be taken once you have conceived. Femara is usually taken once a day or once every other day when used to treat or protect against breast cancer recurrence in postmenopausal women. Be cautious when driving or operating machinery if Femara makes you dizzy or tired. Your doctor may wish to monitor your bone mineral density (BMD) while you are taking Femara as it may lower your BMD. Research has shown that treatment with aromatase inhibitors like Femara can extend the length of time for a breast cancer recurrence or breast cancer spreading in the body. In one study, over 70% of women had a disease-free survival period for up to 8 years. Studies that have compared tamoxifen with aromatase inhibitors (AIs) such as Femara in early-stage breast cancer have shown that five years of treatment with AIs was more effective than tamoxifen at prolonging the time until a breast cancer comes back or having breast cancer spread in the body. There is also a benefit to switching to an AI after 2 or 3 years on tamoxifen or continuing an AI after 5 years of tamoxifen treatment (rather than stopping treatment altogether). However, there is no benefit to switching compared to using letrozole alone for 5 years; however, switching may be a reasonable option for patients who experience intolerable side effects with either drug. Some women may benefit from extended therapy past 5 years based on the risk of disease recurrence, side effects, and previous treatments. The American Society of Clinical Oncology (ASCO) recommends that for women on extended Femara treatment, 10 years should be the maximum duration of therapy. Deciding to extended Femara therapy should be a shared decision based on the risk of disease recurrence, drug side effects, disease status (node-positive/negative disease), and patient preference. Longer duration of Femara use has been associated with increased bone fractures and heart side effects, as well as treatment discontinuation. Treatment with Femara should be discontinued if breast cancer returns. Medicines that interact with Femara may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Femara. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Common medications that may interact with Femara include: antiandrogens, such as apalutamide aprepitant cannabidiol cimetidine citalopram clobazam clopidogrel dabrafenib echinacea HIV medications, such as darunavir, efavirenz hormones, such as estrone, ethinyl estradiol, or hydroxyprogesterone ivacaftor mifepristone oxcarbazepine St. John’s Wort tacrolimus or sirolimus thalidomide tamoxifen warfarin, legal steroid reviews. Note that this list is not all-inclusive and includes only common medications that may interact with Femara. You should refer to the prescribing information for Femara for a complete list of interactions. More about Femara (letrozole) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Compare Alternatives Support Group Pricing & Coupons En Espanol 57 Reviews Generic Availability Drug class: aromatase inhibitors. Patient Information Femara (Advanced Reading) Professional resources. 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